科学研究 | 汪舰 博士

汪舰博士

研究员、博导

2013/01至今,清华大学药学院,研究员,博导 2009/07-2012/12,新加坡国立大学化学系,Tenure-Track Assistant Professor,博导 2007/07-2009/06,美国加州斯克里普斯研究所(Scripps),博士后 2007/07-2009/06,美国诺华制药圣地亚哥研发部(GNF),访问科学家 2003/08-2007/06,美国新墨西哥大学,博士 1997/09-2001/06,中科院感光化学所 1993/09-1997/07,安徽师范大学,学士


研究方向

2000年以来,人们关注的重点已转向了生命科学。一系列重要的“生命难题”需要攻克,比如癌症、老年痴呆症等,它们已成为21世纪威胁人类健康的主要杀手。如何快速开发新药来治疗这些疾病已经不仅仅是科学研究的问题,它也成为了国家的战略需求。新时代下的药物研发已经不再是单一学科的简单信息处理,多学科交叉、高信息量科学处理、大数据等手段综合协调指导的科学药物研发已经成为了一种新趋势。我们课题组的主要研究兴趣在于“药学、合成化学、生物学信息综合指导下的疾病探索和药物研发”。
疾病研究与药物开发
基于ALK突变及双靶点的肺癌小分子药物开发
基于新机制的治疗老年痴呆症的新药开发
基于革兰氏阴性菌耐药性的抗生素开发
化学新工具开发用于合成生物活性分子
氮杂卡宾有机催化(包括不对称)
过渡金属碳氢官能团化-合成杂环
有机催化“Click Chemistry”合成杂环
光催化(包括不对称)合成杂环

获奖与荣誉

荣获2015年拜耳研究员奖
聘为欧洲杂志(Natural Products Against Cancer)的主编(2012-2014)
荣获2013年Asia Core Program Lectureship(日本)
荣获2013年Asia Core Program Lectureship(中国)
荣获新加坡南洋理工大学Nanyang Assistant Professorship(2009)
荣获新加坡国立大学Assistant Professorship(2009)
荣获2006年中国国家优秀自费留学生奖学金(美国)
荣获2007年美国Sigma Xi杰出研究奖
荣获2007年美国新墨西哥大学杰出博士称号
荣获2006-2007年度美国新墨西哥大学院长论文奖学金

近期代表性学术论著

1.Wu, J. C.; Zhao, C. G.; Wang, J*; Enantioselective Intermolecular Enamide-Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes, J. Am. Chem. Soc., 2016, 138, 4706.
2.Zhao, C. G.; Li, F. Y.; Wang, J*; N-heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones, Angew. Chem. Int. Ed., 2016, 55, 1820.
3.Wu, J. C.; Xu, W. B.; Yu, Z.-X.*; Wang, J*; Ruthenium-catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study, J. Am. Chem. Soc., 2015, 137, 9489.
4.Wu, Z. J.; Li, F. Y.; Wang, J*; Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid, Angew. Chem. Int. Ed., 2015, 54, 1629.
5.Li, F. Y.; Wu, Z. J.; Wang, J*; Oxidative Enantioselective α-Fluorination of Aliphatic Aldehydes Enabled by N-Heterocyclic Carbene Catalysis, Angew. Chem. Int. Ed., 2015, 54, 656.
6.Li, W. J.; Wang, J*; Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition, Angew. Chem. Int. Ed., 2014, 53, 14186.
7.Wang, L.; Huang, J. Y.; Liu, H.; Peng, S. Y.; Jiang, X.-F.*; Wang, J.* Palladium-catalyzed Oxidative Cycloaddition via C–H/N–H Activation: Access to Benzazepines, Angew. Chem. Int. Ed., 2013, 52, 1768.
8.Boitano, A. E.; Wang, J.; Romeo, R.; Bouchez, L. G.; Parker, A. E; Sutton, S. U.; Walker, J. R.; Flaveny, C. A.; Perdew, G. H; Denison, M. S.; Schultz, P. G., Cooke, M. P. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells, Science, 2010, 329, 1345-1348.
9.Zhu, S. T.; Wurdak, H.; Wang, J.; Lyssiotis, C. A.; Peters, E. C.; Cho, C. Y.; Wu, X.; Schultz, P. G. A Small Molecule Primes Embryonic Stem Cells for Differentiation, Cell Stem Cell, 2009, 4(5), 416-426.
10.Wang, J.; Xie, H.-X.; Li, H.; Zu, L.-S.; Wang, W. A Highly Stereoselective Hydrogen-Bond-Mediated Michael-Michael Cascade Process through Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2008, 47, 4177.
11.Wang, J.; Li, H.; Zu, L.-S.; Wang, W. Organcatalytic Enantioselective Conjugate Additions to Enones, J. Am. Chem. Soc., 2006, 128, 12652.
12.Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W. Organocatalytic Enantioselective Cascade Michael-Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes, Angew. Chem. Int. Ed., 2007, 46, 9050.
13.Wang, J.; Li, H.; Wang, W.; Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes, Angew. Chem. Int. Ed., 2005, 44, 1369.
14.Zu, L.-S.; Wang, J.; Li, H.; Xie, H.-X.; Jiang, W.; Wang, W. Enantioselective Organcatalytic Domino Michael-Aldol Reactions of alfa, beta b-Unsaturated Imides, J. Am. Chem. Soc., 2007, 129, 1036.
15.Xie, H.-X.; Zu, L.-S.; Li, H.; Wang, J.; Wang, W. Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions. Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes, J. Am. Chem. Soc., 2007, 129, 10886.
16.Wang, W. Li, H.; Wang, J.; Zu. L.-S. Enantioselective Organcatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromans, J. Am. Chem. Soc., 2006, 128, 10354.
17.Zu, L.-S.; Li, H.; Xie, H.-X.; Wang, J.; Jiang, W.; Tang, Y.; Wang, W. Synthesis of Highly Functionalized Chiral Cyclopentanes by Catalytic Enantio- and Diasterselective Double Michael Addition, Angew. Chem. Int. Ed., 2007, 46, 3732.
18.e Frutos, S.; Caldwell, E.; Nitta, C. H.; Kanagy, N. L.; Wang, J.; Wang, W.; Walker, M. K.; Bosc, L. V. G. NFATc3 Contributes to Intermittent Hypoxia-Induced Arterial Remodeling in Mice, American Journal of Physiology, 2010, 299, 356.

专利

1.Wang, W.; Wang, J.; and Li, H. Organocatalysts and Methods of Use in Chemical Synthesis, EU Patent, WO2006007586 (2006).
2.Jiang, X. F.; Wang, J.; Qiao, R.; Liu, H.; Zhongguo Faming Zhuanli Shengqing, 201210086826.5.
3.Jiang, X. F.; Wang, J.; Liu, H.; Li W. J.; Zhongguo Faming Zhuanli Shengqing, 201210093045.9.
4.Jiang, X. F.; Wang, J.; Liu, H.; Li W. J.; Zhongguo Faming Zhuanli Shengqing, 201210099868.2.
5.Jiang, X. F.; Wang, J.; Liu, H.; Li W. J.; Zhongguo Faming Zhuanli Shengqing, 201210174908.5.