Faculty | Wei Guo, Ph.D.

Wei Guo

Research associate professor

After graduating from Institute of Neuroscience, CAS, Dr. Guo finished his postdoctoral training at Tsinghua University and then worked as a research scientist at GlaxoSmithKline, R&D, China. He had been the Co-PI of BaiLu’s lab at Tsinghua University since 2013, and accepted his current position as a research assistant professor of School of Pharmaceutical Sciences in 2015. He was promoted to research associate professor in 2020.



Bio

1.Biography:After graduating from Institute of Neuroscience, CAS, Dr. Guo       finished his postdoctoral training at Tsinghua University and then worked as a research scientist at GlaxoSmithKline, R&D, China. He had been the Co-PI of BaiLu’s lab at Tsinghua University since 2013, and accepted his current position as a research assistant professor of School of Pharmaceutical Sciences in 2015. He was promoted to research associate professor in 2020.
 
2. Research Interests: Dr. Guo’s research focuses on the basic and translational research of BDNF in neurodegenerative diseases. He is also interested in developing therapeutic antibodies and studying how to facilitate the biomacromolecule drugs to cross the Blood-brain barrier

3. Training:   Dr. Guo earned a biochemistry bachelor’s degree from Nanjing University and a PhD degree in neuroscience at Institute of Neuroscience, CAS. He completed his postdoctoral training at Tsinghua University, working with Prof. Bai Lu. And then he trained and worked at GlaxoSmithKline, R&D, China for drug discovery and development.
 
4.Why SPS:My goal of research is to invent efficient drugs for improving people’s health. I believe this goal will be ideally achieved, working with these great colleagues at SPS.

 

Research

1.Area of Investigation: Neurotrophin, Neurodegenerative diseases, Drug discovery,  Therapeutic antibodies,  Blood-brain barrier
 
2.Achievements: (1) ILK-PI3K-GSK3b pathway in neuronal polarity (Publications in Cell,Dev. Biol.) (2)BDNF signaling kinetics and application in neurodegeneration (publication in J. Cell Sci.) (3) TrkB agonistic antibodies for therapy of neurodegenerative diseases and POF (Publications in Nat. Comm., Theranostics, and Neurobio. Dis.) (4) An APP knock-in rat model for AD (Publications in Cell Res.)
 
3.Professional titles: Research associate professor 
 
4. Education:
1997-2001 Department of Biochemistry, Nanjing University, B.S.                                         
2001-2008  Institute of Neuroscience, SIBS, CAS; NIBS, Beijing,Ph.D

Publications

1. Xunsi Qin, Yue Zhao, Tianyi Zhang, Chenghong Yin,Jie Qiao, Wei Guo*, Bai Lu*. (2022) TrkB agonist antibody ameliorates fertility loss in aged and cyclophosphamide-induced premature ovarian failure model mice. Nature Communication, in press. (*Correspondence author)
2. Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo*, Bai Lu*. (2021) An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research. https://www.nature.com/articles/s41422-021-00582-x (*Correspondence author)
3. Shudan Wang, Hongyang Yao, Yihua Xu, Rui Hao, Wen Zhang, Hang Liu, Ying Huang, Wei Guo*, Bai Lu*. Therapeutic potential of a TrkB agonistic antibody for Alzheimer’s disease. Theranostics.2020. 10(15): 6854-6874. (*Correspondence author)
4. He You, Pengcheng Chu, Wei Guo, Bai Lu*. (2020) A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control. Molecular Metabolism. 31: 109-123.
5. Jianying Shen, Dang Sun, Jingyu Shao, Yanbo Chen, Keliang Pang, Wei Guo, Bai Lu*. (2019) Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation. Cells. 8, 932; doi:10.3390/cells8080932
6. Fang Han, Xiaoming Guan, Wei Guo*, Bai Lu*. (2019) Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury. Neurobiology of Disease. 127: 570-581. (*Correspondence author)
7. Wei Guo#, Keliang Pang#, Yanbo Chen, Shudan Wang, Heng Li, Yihua Xu, Fang Han, Hongyang Yao, Hang Liu, Vanessa Lopes-Rodrigues, Dang Sun, Jingyu Shao, Jianying Shen, Yang Dou, Wen Zhang, He You, Wutian Wu, Bai Lu*. (2019) TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration. Neurobiology of Disease. 132: 104590. (#Equal contribution)
8. Wei Guo, Guhan Nagappan and Bai Lu. (2018) Differential effects of transient and sustained activation of BDNF-TrkB signaling. Developmental Neurobiology. 2018 July; 78 (7): 647-659, DOI 10.1002/dneu.22592. Invited review.
9. Zuying Chai#, Changhe Wang#, Rong Huang, Yuan Wang, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou*. (2017) CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron. Dec 20; 96(6): 1317-1326.e4. (#These authors contributed equally to this work.)
10. Keliang Pang, He You, Yanbo Chen, Pengcheng Chu, Meiqing Hu, Jianying Shen, Wei Guo, Can Xie, Bai Lu (2017) MagR alone is insufficient to confer cellular calcium responses to magnetic stimulation. Frontiers Neural Circuits. 11:11.doi: 10.3389/fncir.2017.00011.
11. Petti T Pang, Guhan Nagappan, Wei Guo, Bai Lu. (2016). Extracellular and intracellular cleavages of proBDNF required at two distinct stages of late-phase LTP. npj Science of Learning. 2016. 1, 16003; doi:10.1038/npjscilearn.2016.3; published online 11 May 2016
12. Wei Guo, Yuanyuan Ji, Sudan Wang, Yun Sun, Bai Lu. Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions. J. Cell Sci. 2014 May 15; 127(10): 2249-2260.
13. Wei Guo, Hui Jiang, Virginia Gray, Shoukat Dedhar and Yi Rao. Role of the Integrin-Linked Kinase (ILK) in Determining Neuronal Polarity. Developmental Biology. 2007 Jun 15; 306(2): 457-68.
14. Hui Jiang, Wei Guo, Xinhua Liang and Yi Rao. Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms--Critical Roles of GSK-3β and Its Upstream Regulators. Cell. 2005 Jan 14; 120(1): 123-35.
15. Weiying Yu#, Wei Guo# and Linyin Feng. Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion. FEBS Letters, 2004 Nov 5; 577(1-2): 87-92 (# These authors contributed equally to this work.)


Patents:

1. ANTI-TRKB AGONIST ANTIBODIES BINDING TO D5 DOMAIN OF TRKB AND METHODS OF PROMOTING NEURONAL SURVIVAL IN MOTOR NEURON INJURY, STROKE OR GLAUCOMA. LU BAI, GUO WEI, YAO HONGYANG. Patent number: US 10941203 B2.
2. NOVEL ANTI-TRKB ANTIBODIES. LU BAI, GUO WEI, YAO HONGYANG. Application No. PCT/CN2018/079109. Publication No. WO2018/166495 A1.
3. NOVEL METHOD FOR PRODUCING ANTIBODIES. LU BAI, YAO HONGYANG, GUO WEI. Application No. PCT/CN2018/085960. Publication No.  WO2018/205917 A1.
4. ALZHEIMER'S DISEASE ANIMAL MODEL AND USE THEREOF. LU BAI, PANG KELIANG,GUO WEI. Application No. PCT/CN2019/078753. Publication No. WO2019/179445 A1.  


Others:

Contact Information:Email: wguo@tsinghua.edu.cn, Phone: 86-10-62787837