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Latest Research Discoveries | Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.
We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of rationally designed and bioinspired transformations, including a Moore rearrangement to assemble the monomeric hydroquinone precursor, homodimerization through double Michael addition to construct the planar A/B/C tricyclic framework, and a tandem Diels–Alder reaction/carbonyl–ene cyclization to forge the congested D/E/F tricyclic cage motif. Unequivocal evidence for the elucidated structure of homodimericin A was also provided by this study.
About Us
A Letter from the Dean
Mission
At a Glance
History
Organization
Advisory Board
Faculty
Tenure Track
Teaching
Experimental Techniques
Research
Research
Research Overview
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Academics
Undergraduate
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Postdoctoral
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About Center of Pharmaceutical Technology
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