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Latest Research Discoveries | Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.
The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state involving a cyclic aza-ortho-xylylene intermediate to afford the indoline structures with good to excellent enantioselectivity. The synthetic utility of this method is demonstrated by the asymmetric synthesis of a key intermediate to the natural product minfiensine and the identification of a chiral lead compound to repress antibiotic resistance.
About Us
A Letter from the Dean
Mission
At a Glance
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Organization
Advisory Board
Faculty
Tenure Track
Teaching
Experimental Techniques
Research
Research
Research Overview
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Academics
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Postdoctoral
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International Exchange
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