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Latest Research Discoveries | Yefeng TANG publishes "Enantioselective and Collective Total Syntheses of Xanthanolides" in Angew. Chem. Int. Ed.
An enantioselective synthesis of (+)-8-epi-xanthatin hinging on a chiral phosphoric acid catalyzed tandem allylboration/lactonization reaction is reported. With (+)-8-epi-xanthatin as the precursor, the collective synthesis of a series of synthetically challenging xanthanolides was also accomplished. Among them, xanthipungolide, one of the most complex xanthanolide monomers, was accessed through a bioinspired tandem double-bond isomerization/6π electronic cyclization/intramolecular Diels–Alder reaction, and pungiolides A, B, D, E, and L–N, a group of xanthanolide dimers, were assembled through a bioinspired Diels–Alder dimerization followed by late-stage diversification.
About Us
A Letter from the Dean
Mission
At a Glance
History
Organization
Advisory Board
Faculty
Tenure Track
Teaching
Experimental Techniques
Research
Research
Research Overview
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Academics
Undergraduate
Graduate
Postdoctoral
Alumni
International Exchange
Core Facilities
About Center of Pharmaceutical Technology
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Overview
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