Research |
Yinqing Li, Ph.D.

Yinqing Li joined Tsinghua faculty in 2018 and is currently an assistant professor in the School of Pharmaceutical Sciences. He received his B.S. in microelectronics from Fudan University in 2008 and his S.M. and PhD in electrical engineering and computer science from Massachusetts Institute of Technology in 2012 and 2016, where he worked with Dr. Feng Zhang and Dr. Aviv Regev. He then performed postdoctoral research with Dr. Guoping Feng in the Broad Institute of Harvard and MIT and Stanley Center for Psychiatric Research. During the course of his doctoral and postdoctoral research, Yinqing pioneered the engineering and characterization of cell and gene editing tools, co-invented single-nucleus transcriptome profiling technologies, and broadened these tools to systematically interrogate cortical-thalamic circuity function and in disease models.


Research Interests
Yinqing Li has a longstanding interest in developing technologies for better diagnosis and management of complex diseases. In particular, his research focuses on methods for identifying key molecular and cell players in the development of diseases and methods for gene and cell editing. Specific approaches include: single cell multi-omics spanning epigenetics, transcriptome, and signaling pathway profiling, discovery of novel genome and epigenome editing tools, and statistical inference and machine learning algorithms for high throughput data mining and processing.


Honors and awards
2019       MIT Technology Review, 35 under 35, China
2016       Extraordinary Potential Prize of 2016 Chinese Government Award for Students Abroad
2016       Wenner-Gren Fellowship
2013       McGovern Institute Fellowship


Selected Publications
1. Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, Arias-Garcia MA, Guo B, Yao AY, Blosser TR, Wimmer RD, Aida T, Atamian A, Naik T, Sun X, Bi D, Malhotra D, Hession CC, Shema R, Gomes M, Li T, Hwang E, Krol A, Kowalczyk M, Peça J, Pan G, Halassa MM, Levin JZ, Fu Z, Feng G. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020, 583(7818):819-824.

2. Habib N*, Li Y*, Heidenreich M, Swiech L, Avraham-Davidi I, Trombetta JJ, Hession C, Zhang F, Regev A. Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. SCIENCE. 2016, 353(6302):925-8.

3. Li Y*, Jiang Y*, Chen H*, Liao W, Li Z, Weiss R, Xie Z. Modular construction of mammalian gene circuits using TALE transcriptional repressors. NATURE CHEMICAL BIOLOGY. 2015, 11(3):207-13.



Dr. Li's Personal Webpage: http://web.mit.edu/yinqingl/www/