(1) Tumor detection and diagnosis  
Selective RNA-cleaving Fluorescent DNAaymes (RFD) can detect their specific ligands rapidly, sensitively, and accurately. These RFD probes have the potential to accomplish the requirement that to recognize tumors. Thus it is essential to develop tumor-specific RFD probes and the RFD detection kits. Our research is based on the SELEX technique(systematic evolution of ligands by exponential Enrichment),to obtain the DNA pool that can specifically identify tumor metabolite. RFD probe of the DNA pool can also distinguish tumor cells from normal cells and classify sub-type of tumor. It will be a new method to find biomarker for individualized treatment, tumor prevention and early diagnosis.  
 
(2) Pokemon signaling pathways  
Pokemon is a ubiquitous transcription factor of the POZ family composed of BTB/POZ domain at the N terminus and a Kruppel zinc finger domain at the C terminus. Pokemon plays a pivotal role in tumorigenesis as a proto-oncogene localized upstream of several oncogenes. It is may be efficent target for antitumor drug research. In our group, pokemon mediated tumor signal transduction pathways were studied using advanced technology and methods in the field of functional genomics and bioinformatics. Pokemon related gene  regulatory networks were established in breast and liver cancers, which included cell growth, migration, apoptosis, cell cycle, multidrug resistance signaling pathways and nucleoside, amino acid, lipid  material metabolism pathways. It will establishe a theoretical basis for the study on multigene regulatory network of tumor formation, selection and combination of anti-cancer drug targets with independent intellectual property rights.  
 
(3) High-throughput screening method and multi-targeted anticancer drug discovery  
Cancer is a disease of multiple genes and found novel multi-targeted drugs with high efficiency and low toxicity is important. A wide range of screening can significantly improve the multi-target compound hit rate and avoid patent protection. Combined with National University of Singapore, We have developed the support vector machine (SVM) multi-target screening system, which can meet the requirements of a wide range of drug screening. By using this system, the multiple target compounds were identified and synthesized by our lab.  
   
(4) Tumor metabolomics and proteomics  
Because there are a great variety of intracellular metabolites and proteins, and their properties are great different. Using the traditional analysis methods will lead to a large amount of information loss. Aiming to these problems, our research group is dedicated to the development of new strategies for targeted analysis of metabolites and proteomics in biological samples. Using these strategies, a more comprehensive metabolites and proteins information can be obtained. Our main research interest is the use of a variety of derivate means to derivatize the same kind of metabolites of proteins. It could largely increase their detection sensitivity and finally appiled for clinical sample analysis, which could provide a technical platform for the discovery of tumor biomarkers.  
   
(5) Conjugated polymer-based bioanalysis, cell imaging, and drug delivery  
Conjugated polymers have received considerable attention and have been widely studied in fluorescent biosensing and cell imaging. We focuse on the following areas: 1) design and synthesis of novel fluorescent probes for sensing and drug delivery; 2) develop biosensing methods targeting different biomarkers for the application of diagnosis and post evaluation; 3) cell imaging study for characterizing apoptosis and autophagy process.

Tumor detection based on RFD probes: We got some probes which could response to metabolites of MDA-MB-231 using SELEX screening. A partial probes could response and bind to metabolites of MDA-MB-231 with high specific advantage. These probes also showed higher effect on recognization to tumor tissue. 

Pokemon signal transduction pathways: Our results demonstrated a negative correlation between pokemon expression and survival rate of breast cancer patents. Pokemon could be a negative factor for prognosis. 

Conjugated polyelectrolyte-based fluorescence assays for caspases, phosphatases, and proteases: We have developed conjugated polyelectrolyte-based fluorescence assays for caspase 3 and 8, phosphatases, and proteases. Such simple, convenient, and sensitive methods can be generalized to other similar targets for further application in disease diagnosis and evaluation.

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Selected publications 

2. Wang, Y.; Gao, D.; Chu, B.; Gao, C.; Cao, D.; Liu, H.;    Jiang, Y*., Exposure of CCRF-CEM cells to acridone derivative 8a triggers tumor death via multiple mechanisms.    Proteomics    2016,    16 (7), 1177-1190.  
3. Chen, Y.; Gao, D.; Liu, H.; Lin, S.;    Jiang, Y*., Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening.    Anal. Chim. Acta    2015,    898, 85-92.  
4. Mao, Y.; Liu, M.; Tram, K.; Gu, J.; Salena, B. J.;    Jiang, Y*..; Li, Y., Optimal DNA Templates for Rolling Circle Amplification Revealed by In Vitro Selection.    Chemistry-a European Journal    2015,    21 (22), 8069-8074.  
5. Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Chen, S.; Zhang, P.; Zhang, C.; Tan, C.; Gao, C.; Chen, Z.;    Jiang, Y*.; Chen, Y. Z., Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites.    Scientific Reports    2015,    5.  
6. Zhang, B.; Chen, K.; Wang, N.; Gao, C.; Sun, Q.; Li, L.; Chen, Y.; Tan, C.; Liu, H.;    Jiang, Y*., Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents.    Eur. J. Med. Chem.    2015,    93, 214-226.  
7. Mao, Y.; Chen, Y.; Li, S.; Lin, S.;    Jiang, Y*.., A Graphene-Based Biosensing Platform Based on Regulated Release of an Aptameric DNA Biosensor.    Sensors (Basel, Switzerland)    2015,    15 (11), 28244-56.  
8. Gao, C.; Li, B.; Zhang, B.; Sun, Q.; Li, L.; Li, X.; Chen, C.; Tan, C.; Liu, H.;    Jiang, Y*., Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents.    Bioorg. Med. Chem.    2015,    23 (8), 1800-1807.  
9. Li, X.; Gao, C.; Yang, T.; Zhang, B.; Tan, C.; Liu, H.;    Jiang, Y*., A POCl3-mediated synthesis of substituted fused azoacridones derivatives.    Rsc Advances    2015,    5 (36), 28670-28678.  
10. He, S.; Qu, L.; Shen, Z.; Tan, Y.; Zeng, M.; Liu, F.;    Jiang, Y*.; Li, Y., Highly Specific Recognition of Breast Tumors by an RNA-Cleaving Fluorogenic DNAzyme Probe.    Analytical Chemistry    2015,    87 (1), 569-577.  
11. Chu, B.; Liu, F.; Li, L.; Ding, C.; Chen, K.; Sun, Q.; Shen, Z.; Tan, Y.; Tan, C.;    Jiang, Y*., A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.    Cell death & disease    2015,    6, e1686.  
12. Chen, K.; Chu, B.-z.; Liu, F.; Li, B.; Gao, C.-m.; Li, L.-l.; Sun, Q.-s.; Shen, Z.-f.;    Jiang, Y*., New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway.    Acta Pharmacologica Sinica    2015,    36 (9), 1074-1084.  
13. Gao, F.; Liu, F.; Zheng, J.; Zeng, M.;    Jiang, Y*., A Catalytic DNA Probe with Stem-loop Motif for Human T47D Breast Cancer Cells.    Analytical Sciences    2015,    31 (8), 815-822.  
14. Liu, H.; Li, X.; Liu, F.; Tan, Y.;    Jiang, Y*., A simple and novel amide ligand based on quinoline derivative used for palladium-catalyzed Suzuki coupling reaction.    Journal Of Organometallic Chemistry    2015,    794, 27-32.  
15. Tao, L.; Zhu, F.; Xu, F.; Chen, Z.;    Jiang, Y*.; Chen, Y. Z., Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs.    Pharmacological Research    2015,    102, 123-131.  
16. Qin, C.; Tao, L.; Phang, Y. H.; Zhang, C.; Chen, S. Y.; Zhang, P.; Tan, Y.;    Jiang, Y*.; Chen, Y. Z., The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications.    Scientific Reports    2015,    5.  
17. Tao, L.; Zhu, F.; Qin, C.; Zhang, C.; Xu, F.; Tan, C. Y.;    Jiang, Y*.; Chen, Y. Z., Nature's contribution to today's pharmacopeia.    Nature biotechnology    2014,    32 (10), 979-80.  
18. Zhang, B.; Li, X.; Li, B.; Gao, C.;    Jiang, Y*., Acridine and its derivatives: a patent review (2009-2013).    Expert Opinion on Therapeutic Patents    2014,    24 (6), 647-664.  
19. Xin, T.; Zhang, C.; Tan, C.;    Jiang, Y*., Biological Evaluation and Structure Modification of (S)-3-Aminopyrrolidine Derivatives.    Chemical Research in Chinese Universities    2014,    30 (1), 91-97.  
20. Wu, Q.; Gao, D.; Wei, J.; Jin, F.; Xie, W.;    Jiang, Y*.; Liu, H., Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening.    Chemical Communications    2014,    50 (21), 2762-2764.  
21. Li, B.; Gao, C.-M.; Sun, Q.-S.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.;    Jiang, Y*., Novel synthetic acridine-based derivatives as topoisomerase I inhibitors.    Chin. Chem. Lett.    2014,    25 (7), 1021-1024.  
22. Gao, D.; Jin, F.; Liu, H.; Wang, Y.;    Jiang, Y*., Metabonomic study on the antitumor effect of flavonoid derivative 3d in HepG2 cells and its action mechanism.    Talanta    2014,    118, 382-388.  
23. Chen, X.; Gao, D.; Liu, F.; Gao, X.; Wang, S.; Zhao, Y.; Liu, H.;    Jiang, Y*., A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry.    Anal. Chim. Acta    2014,    836, 61-71.  
24. Ding, C.; Zhang, C. L.; Zhang, M. L.; Chen, Y. Z.; Tan, C. Y.; Tan, Y.;    Jiang, Y*., Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.    Future Med Chem    2014,    6 (16), 1771-1789.  
25. Qu, L.; Ali, M. M.; Aguirre, S. D.; Liu, H.;    Jiang, Y*.; Li, Y., Examination of Bacterial Inhibition Using a Catalytic DNA.    PLoS One    2014,    9 (12).  
26. Chen, Z.; Liu, F.; Zhang, N.; Cao, D.; Liu, M.; Tan, Y.;    Jiang, Y*., p38 beta, A Novel Regulatory Target of Pokemon in Hepatic Cells.    Int. J. Mol. Sci.    2013,    14 (7), 13511-13524.  
27. Jin, F.; Gao, D.; Wu, Q.; Liu, F.; Chen, Y.; Tan, C.;    Jiang, Y*., Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor.    Bioorg. Med. Chem.    2013,    21 (18), 5694-5706.  
28. Jin, F.; Gao, D.; Zhang, C.; Liu, F.; Chu, B.; Chen, Y.; Chen, Y. Z.; Tan, C.;    Jiang, Y*., Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment.    Bioorg. Med. Chem.    2013,    21 (3), 824-831.  
29. Jin, X. L.; Sun, Q. S.; Liu, F.; Yang, H. W.; Liu, M.; Liu, H. X.; Xu, W.;    Jiang, Y*., microRNA 21‐mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation.    Journal of Cellular Biochemistry    2013,    114, 1625-1633.  
30. Lang, X.; Li, L.; Chen, Y.; Sun, Q.; Wu, Q.; Liu, F.; Tan, C.; Liu, H.; Gao, C.;    Jiang, Y*., Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents.    Bioorg. Med. Chem.    2013,    21 (14), 4170-4177.  
31. Lang, X.-L.; Sun, Q.-S.; Chen, Y.-Z.; Li, L.-L.; Tan, C.-Y.; Liu, H.-X.; Gao, C.-M.;    Jiang, Y*., Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor.    Chin. Chem. Lett.    2013,    24 (8), 677-680.  
32. Liu, R.; Tan, Y.; Zhang, C.; Wu, J.; Mei, L.;    Jiang, Y*.; Tan, C., A real-time fluorescence turn-on assay for trypsin based on a conjugated polyelectrolyte.    Journal of Materials Chemistry B    2013,    1 (10), 1402-1405.  
33. Wu, J.; Tan, Y.; Xie, Y.; Wu, Y.; Zhao, R.;    Jiang, Y*.; Tan, C., Diazobenzene-containing conjugated polymers as dark quenchers.    Chemical Communications    2013,    49 (97), 11379-11381.  
34. Zhang, N.-N.; Sun, Q.-S.; Chen, Z.; Liu, F.;    Jiang, Y*., Homeostatic regulatory role of Pokemon in NF-kappa B signaling: stimulating both p65 and I kappa B alpha expression in human hepatocellular carcinoma cells.    Molecular and Cellular Biochemistry    2013,    372 (1-2), 57-64.  
35. Gao, D.; Liu, H.; Lin, J.-M.; Wang, Y.;    Jiang, Y*., Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device.    Lab on a Chip    2013,    13 (5), 978-985.  
36. Wang, Y.; Gao, D.; Chen, Z.; Li, S.; Gao, C.; Cao, D.; Liu, F.; Liu, H.;    Jiang, Y*., Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents.    Plos One    2013,    8 (5), e63572.  
37. Gao, C. M.; Li, S. F.; Lang, X. L.; Liu, H. X.; Liu, F.; Tan, C. Y.;    Jiang, Y*., Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands.    Tetrahedron    2012,    68 (38), 7920-7925.  
38. Gao, X.; Wu, H.; Lee, K.-C.; Liu, H.; Zhao, Y.; Cai, Z.;    Jiang, Y*., Stable Isotope N-Phosphorylation Labeling for Peptide de Novo Sequencing and Protein Quantification Based on Organic Phosphorus Chemistry.    Analytical chemistry    2012,    84 (23), 10236-10244.  
39. Han, B. C.; Ma, X. H.; Zhao, R. Y.; Zhang, J. X.; Wei, X. N.; Liu, X. H.; Liu, X.; Zhang, C. L.; Tan, C. Y.;    Jiang, Y*.; Chen, Y. Z., Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries.    Chem Cent J    2012,    6.  
40. Jin, F.; Zhang, N.; Tan, C.; Gao, D.; Zhang, C.; Liu, F.; Chen, Z.; Gao, C.; Liu, H.; Li, S.;    Jiang, Y*., 2'-Chloro-4'-aminoflavone Derivatives Selectively Targeting Hepatocarcinoma Cells: Convenient Synthetic Process, G2/M Cell Cycle Arrest and Apoptosis Triggers.    Archiv Der Pharmazie    2012,    345 (7), 525-534.  
41. Jin, Y. B.; Luan, X. D.; Liu, H. X.; Gao, C. M.; Li, S. F.; Cao, D. L.; Li, X. Y.; Cai, Z. W.;    Jiang, Y*., Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry.    Talanta    2012,    89, 70-76.  
42. Zhu, F.; Ma, X. H.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Zhang, C. L.; Tan, C. Y.; Chen, Y. Z.;    Jiang, Y*., Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs.    Plos One    2012,    7 (7).  
43. Zhao, R.; Xie, Y. H.; Tan, Y.; Tan, C. Y.;    Jiang, Y*., Binding of a bcl-2 Family Inhibitor to Bovine Serum Albumin: Fluorescence Quenching and Molecular Docking Study.    Protein and Peptide Letters    2012,    19 (9), 949-954.  
44. Zhang, X.; Tan, Y.; Zhao, R.; Chu, B.; Tan, C.;    Jiang, Y*., Site-directed Mutagenesis Study of the Ile140 in Conserved Hydrophobic Core of Bcl-x(L).    Protein and Peptide Letters    2012,    19 (9), 991-996.  
45. Zhang, J. X.; Han, B. C.; Wei, X. N.; Tan, C. Y.; Chen, Y. Z.;    Jiang, Y*., A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands.    Plos One    2012,    7 (6).  
46. Zhang, J.; Jia, J.; Zhu, F.; Ma, X.; Han, B.; Wei, X.; Tan, C.;    Jiang, Y*.; Chen, Y., Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors.    Molecular bioSystems    2012,    8 (10), 2645-56.  
47. Zhang, C. L.; Tan, C. Y.; Ding, H. W.; Xin, T.;    Jiang, Y*., Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials.    Current Pharmaceutical Design    2012,    18 (20), 2921-2935.  
48. Yang, X. F.; Zu, X. Y.; Tang, J.; Xiong, W.; Zhang, Y.; Liu, F.;    Jiang, Y*., Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation.    Molecular Medicine Reports    2012,    5 (6), 1475-1480.  
49. Xie, Y. H.; Zhao, R.; Tan, Y.; Zhang, X.; Liu, F.;    Jiang, Y*.; Tan, C. Y., Conjugated Polymer-Based Real-Time Fluorescence Caspase Assays.    ACS Applied Materials & Interfaces    2012,    4 (1), 405-410.  
50. Xie, Y. H.; Tan, Y.; Liu, R. X.; Zhao, R.; Tan, C. Y.;    Jiang, Y*., Continuous and Sensitive Acid Phosphatase Assay Based on a Conjugated Polyelectrolyte.    ACS Applied Materials & Interfaces    2012,    4 (8), 3784-3787.  
51. Tian, J.;    Jiang, Y*., Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells.    Molecular Medicine Reports    2012,    6 (6), 1379-1384.  
52. Tan, Y.; Zhang, X.; Xie, Y. H.; Zhao, R.; Tan, C. Y.;    Jiang, Y*., Label-free fluorescent assays based on aptamer-target recognition.    Analyst    2012,    137 (10), 2309-2312.  
53. Liu, K.; Liu, F.; Zhang, N. N.; Liu, S. Y.;    Jiang, Y*., Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703.    Int. J. Mol. Sci.    2012,    13 (5), 5818-5831.  
54. Lin, J. S.; Liu, F.;    Jiang, Y*., Antisense Technologies Targeting Fatty Acid Synthetic Enzymes.    Recent Patents on Anti-Cancer    Drug Discovery    2012,    7 (2), 198-206.  
55. Lin, J.; Jin, X.; Bu, Y.; Cao, D.; Zhang, N.; Li, S.; Sun, Q.; Tan, C.; Gao, C.;    Jiang, Y*., Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway.    Organic & Biomolecular Chemistry    2012,    10 (48), 9734-9746.  
56. Lang, X. L.; Luan, X. D.; Gao, C. M.;    Jiang, Y*., Recent Progress of Acridine Derivatives with Antitumor Activity.    Progress in Chemistry    2012,    24 (8), 1497-1505.  
57. Zu, X.; Ma, J.; Liu, H.; Liu, F.; Tan, C.; Yu, L.; Wang, J.; Xie, Z.; Cao, D.;    Jiang, Y*., Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression.    Breast Cancer Res.    2011,    13, R26.  
58. Zhu, F.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Ma, X.; Jia, J.; Tan, Y.; Cui, C.; Lin, J.; Tan, C.;    Jiang, Y*.; Chen, Y., Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.    Proc. Natl. Acad. Sci. U. S. A.    2011,    108 (31), 12943-12948, S12943/1-S12943/139.  
59. Zhao, R.; Tan, C.; Xie, Y.; Gao, C.; Liu, H.;    Jiang, Y*., One step synthesis of azo compounds from nitroaromatics and anilines.    Tetrahedron Lett.    2011,    52 (29), 3805-3809.  
60. Zhang, Y.; Zu, X. Y.; Luo, W. S.; Tang, S. S.;    Jiang, Y*., siRNA Induced CyclinB1 Knockdown Sensitizes HepG2 Cells to Daunorubicin.    Prog. Biochem. Biophys.    2011,    38 (6), 551-557.  
61. Zhang, D.; Liu, H.; Zhang, S.; Chen, X.; Li, S.; Zhang, C.; Hu, X.; Bi, K.; Chen, X.;    Jiang, Y*., An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry.    Talanta    2011,    84 (3), 614-622.  
62. Zhang, C.; Zhai, X.; Wan, F.; Gong, P.;    Jiang, Y*., 2-Chloro-1- 4-(2-fluorobenzyl)piperazin-1-yl ethanone.    Acta Crystallographica Section E-Structure Reports Online    2011,    67, O708-U2523.  
63. Zhang, C.; Tan, C.; Zu, X.; Zhai, X.; Liu, F.; Chu, B.; Ma, X.; Chen, Y.; Gong, P.;    Jiang, Y*., Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.    Eur. J. Med. Chem.    2011,    46 (4), 1404-1414.  
64. Luan, X.; Gao, C.; Zhang, N.; Chen, Y.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.;    Jiang, Y*., Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors.    Bioorg. Med. Chem.    2011,    19 (11), 3312-3319.  
65. Luan, X.; Gao, C.; Sun, Q.; Tan, C.; Liu, H.; Jin, Y.;    Jiang, Y*., Novel synthetic azaacridine analogues as topoisomerase 1 inhibitors.    Chem. Lett.    2011,    40 (7), 728-729.  
66. Li, Y.; Tan, C.; Gao, C.; Zhang, C.; Luan, X.; Chen, X.; Liu, H.; Chen, Y.;    Jiang, Y*., Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.    Bioorg. Med. Chem.    2011,    19 (15), 4529-4535.  
67. Li, S.; Liu, H.; Jin, Y.; Lin, S.; Cai, Z.;    Jiang, Y*., Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice.    J. Chromatogr., B: Anal. Technol. Biomed. Life Sci.    2011,    879 (24), 2369-2375.  
68. Hu, X.; Gao, C.; Tan, C.; Zhang, C.; Zhang, H.; Li, S.; Liu, H.;    Jiang, Y*., Design and Synthesis of N-phosphoryl Peptide Modified Podophyllotoxin Derivatives as Potent Anticancer Agents.    Protein and Peptide Letters    2011,    18 (12), 1258-1264.  
69. Chen, X. W.; Liu, H. X.; Jin, Y. B.; Li, S. F.; Bi, X.; Chung, S.; Zhang, S. S.;    Jiang, Y*., Separation, identification and quantification of tetrodotoxin and its analogs by LC-MS without calibration of individual analogs.    Toxicon    2011,    57 (6), 938-943.