精准调控免疫系统有望实现对肿瘤、自身免疫疾病、感染性疾病等多种疾病的有效防治。近年来多种免疫治疗靶点及药物的发现为精准调控免疫系统治带来了全新的机遇，但是药物分子自身理化性质导致的不稳定性以及存在于组织、细胞、亚细胞层面的生理屏障严重妨碍了这些药物分子有效作用于靶点从而制约疗效。另一方面，非特异性的脱靶效应也会带来严重的毒副作用。本课题组致力于在药物制剂和免疫治疗的交叉领域展开系列研究来克服上述挑战。主要研究方向包括：（1）设计开发可克服药物不稳定性及有关生理屏障的制剂；（2）调节制剂在多尺度（如组织、细胞、亚细胞）的时空分布并研究其与免疫应答的相互关系；（3）探索制剂在不同疾病（如肿瘤、自身免疫疾病、感染性疾病）治疗中的应用并阐明其作用机制。
蒯锐博士长期致力于药物制剂和免疫治疗的交叉研究，通过“生物启发”的策略构建了一系列基于脂质的纳米制剂克服制约免疫治疗的关键递送瓶颈；阐明了这些制剂在组织、细胞、亚细胞等层面调控药物递送效率的关键原理；建立了相关制剂用于多种疾病防治的方法。早期成果孵化成立了一家名为“EVOQ Therapeutics”的初创公司。
2024 清华大学青教赛一等奖
2024 清华大学药学院优秀教学奖
2021 国家高层次人才青年项目
2018 中国教育部留学基金委“优秀自费留学生”
2017 美国药物科学家协会(AAPS)生物技术创新奖
2017 密歇根大学Norman Weiner 奖学金
2015-2017 美国心脏协会 (AHA) 奖学金
2013 密歇根大学Broomfield 国际留学生奖
2013 四川省优秀硕士论文奖
2011 石药集团优秀学生奖
代表性论文
1.Yu J, Li X, Li J, Sun N, Peng C, Huang J, Li S,
Kuai R*. Single-dose physically crosslinked hyaluronic acid and lipid hybrid nanoparticles containing cyclic guanosine monophosphate–adenosine monophosphate eliminate established tumors.
ACS Nano. 2024;18(43):29942-29955.
2.Li X, Wu C, Li J, Yu J, Yang X, Yu L, Wang C,
Kuai R*. An immunostimulatory liponanogel reveals immune activation-enhanced drug delivery and therapeutic efficacy in cancer.
Journal of Controlled Release. 2024;376:167-183.
3.He J, Wang C, Fang X, Li J, Shen X, Zhang J, Peng C, Li H, Li S, Karp J,
Kuai R*. Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice.
Nature Communications. 2024 ;15(1):8121.
4.Li J, Luo L, He J, Yu J, Li X, Shen X, Zhang J, Li S, Karp JM,
Kuai R*. A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors.
Cancer Research. 2024;84(14):2352-2363.
5.Li X#, Gao J#, Wu C, Wang C, Zhang R, He J, Xia ZJ, Joshi N*, Karp JM*,
Kuai R*. Precise modulation and use of reactive oxygen species for immunotherapy.
Science Advances. 2024;10(20):eadl0479.
6.Wang C, Zhang R, He J, Yu L, Li X, Zhang J, Li S, Zhang C, Kagan JC, Karp JM,
Kuai R*. Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity.
Nature Communications. 2023;14(1):3877.
7.Levy O#,
Kuai R#, Siren EM#, Bhere D, Milton Y, Nissar N, Debiasia M, Heinelt M, Abdi R, Alturki M, Fallatah M, Almalik A, Alhansan AH, Shah K, Karp JM. Shattering the glass ceiling of clinically meaningful mesenchymal stromal cell (MSC) therapies.
Science Advances, 2020, 6 (30), eaba6884.
8.
Kuai R, Sun X, Yuan W, Ochyl LJ, Xu Y, Najafabadi AH, Scheetz L, Yu M, Balwani I, Schwendeman A*, Moon JJ*. Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy.
Journal of Controlled Release, 2018, 282, 131-139.
9.
Kuai R#, Yuan W#, Son S, Nam J, Xu Y, Fan Y, Schwendeman A*, Moon JJ*. Elimination of established tumors with nanodisc-based combination chemoimmunotherapy.
Science Advances. 2018; 4: eaao1736.
10.
Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A*, Moon JJ*. Designer vaccine nanodiscs for personalized cancer immunotherapy.
Nature Materials. 2017, 16 (4), 489-496.
11.
Kuai R, Li D, Chen YE, Moon JJ*, Schwendeman A*. High-density lipoproteins: nature’s multifunctional nanoparticles.
ACS Nano, 2016, 10 (3), 3015–3041.
书的章节
1.Luo L,
Kuai R*, Nanoparticles-assisted peptide cancer vaccine delivery. Cancer Vaccines, Methods in Molecular Biology, published by Springer Nature, 2025.
2.
Kuai R#, Ochyl LJ#, Schwendeman A*, Moon JJ*. Lipid-based nanoparticles for vaccine applications. Biomedical Engineering: Frontier Research and Converging Technologies. 2015, 9, 177-197.
